Inventor, astronaut and scientist Dr. Reed Richards (Ioan Gruffudd) is spearheading a trip to outer space, to the center of a cosmic storm. There he hopes to unlock the secrets of the human genetic codes for the benefit of all humanity. Reed’s crew for the mission includes his best friend, astronaut Ben Grimm (Michael Chiklis); Sue Storm (Jessica Alba), Von Doom’s director of genetic research and Reed’s ex-girlfriend; and Sue’s hot-headed younger brother, pilot Johnny Storm (Chris Evans). With benefactor Von Doom (Julian McMahon) in tow, the four set off for the exploration of a lifetime. The mission is uneventful – until Reed discovers a miscalculation of the speed of the approaching storm. Within minutes, the event threshold is upon them. The space station is engulfed by turbulent clouds of cosmic radiation which genetically transforms the crew. Their DNA is irrevocably altered… and so is their future. Back on earth, the effects of the exposure are quickly revealed. Together, they turn tragedy into triumph and catastrophe into coalition, using their unique and formidable powers to thwart the evil plans of their now steely-eyed, iron-fisted nemesis Dr. Doom and to protect the citizens of New York City.