Detectives respond to a call of a stabbing at a convenience store on North Avenue. The victim is a young man lying in a pool of blood. The convenience store clerks say the suspect ran out of the store. Fortunately, the convenience store has a surveillance video of the crime. The video recorder is removed from the store and taken to the state lab where the tape will be retrieved, copied and reviewed.

Detective Jaime Baynes is called to the scene of a possible homicide. After interviewing a few witnesses, Baynes learns the victim ran 100 yards, coughing up blood along the way. He banged on a couple of doors crying for help, before falling on his back and dying in the grass. In his death grip is a folded-up dollar bill with methamphetamine inside. The medical examiner finds a bullet from a small caliber 25 mm gun had ricocheted around in his body, causing internal bleeding. At the crime scene, where detectives believe the shooting occurred, no shell casings are found. With no suspects or leads, the forensic team tests the methamphetamine for a unique chemical formula, which may lead them to the neighborhood that produced the drugs. Hopefully the drugs' formula and the signature way the drugs were wrapped in the dollar bill, can lead detectives to the source and a possible suspect.

Detectives Hank Veverka and Tom Armelli are called to a possible crime scene. The coroner arrives and finds that the victim's body shows signs of blunt force trauma to the head. While still on scene, the detectives respond to a call from a woman who claims that she was watching the news story of the crime and she believes that the body they found may be her nephew - who had been missing since the previous night. When Detectives Veverka and Armelli arrive at the woman's house, she tells them that she had seen a trail of blood leading upstairs to her nephew's bedrooms the day before. She also reveals that her nephew and his brother have a troubled past, and detectives piece together the evidence to discover what happened.

A young woman is found shot to death in a ransacked apartment. Detectives speculate she may have stumbled upon a robbery. They interview the apartment's residents. They claim to have been out partying the night of the murder. But one resident, the victim's boyfriend, is missing. Detectives discover evidence that sheds doubt on the roommates' testimony. This homicide turns out to be much more complex than a simple robbery, with some very surprising twists.

Detectives Tim Entenok and Joselito Sandoval are called to a crime scene at Brookside Park at 11:00 am, where a missing person is found dead in a 4-foot-diameter sewage drain, in a remote section of the park. The body is found 300 feet deep in the pipe, which has been draining a constant flow of rainwater. When Entenok takes a closer look at the body, he notices that it is maggot-infested: an indication that the body has been in the pipe for over a week. The victim's head, surrounded by a dried pool of blood, seems to have bullet holes, but the maggots preclude an accurate visual assessment. Only an autopsy will determine the cause of death. Meanwhile Sandoval scours the nearby train tracks for additional evidence. A few rocks, stained with a blood-like substance, are collected. The investigation seems to go cold with no leads until a female witness gives them a much-needed break in the case.

On the morning of July 5th, the body of the victim is found lying face up in an abandoned lot that had been used to shoot off guns the night before in celebration of Independence Day. More than 60+ shell casings are collected from the crime scene, which detectives hope will include an essential clue. A tip leads detectives to a possible suspect, who denies any involvement in the killing, although his polygraph may show otherwise. Detectives search his girlfriend's house for other evidence. Meanwhile, rumor on the street is that a high-level dealer was actually the shooter. As their list of suspects grows, the case quickly evolves into what seems to be a conspiracy -- but without an on-the-record eyewitness, Detective Simms won't be able to prove the case.

Detective Mocello responds to the scene of a suspicious fire in the bedroom of a first floor apartment. He doesn't know if it's a homicide, an accident, or a suicide when he arrives. But he soon discovers that the deceased victim's charred body has sustained serious trauma. While arson investigators pick through the soot, Mocello and the team find a gas can, a set of keys in the parking lot and a shoeprint on a nearby railing. Mocello theorizes it could have been a burglary gone wrong. But then Mocello meets with the victim's landlord and learns of a troubled relationship the victim had with a relative. With the evidence they've collected, they'll have to determine whether they should be hunting for a stranger, or a relative.

In the dead of night, homicide detectives, Thompson and Pence are called out to a bloody crime scene: a body, riddled with bullets, is found on a porch in a residential neighborhood. Detectives find the tenant asleep in the house, but they don't know if he is a suspect or a potential witness. The tenant knows the victim, but claims to have no knowledge of the murder, and he seems to have a seal-tight alibi. Evidence at the crime scene: the body, the blood, the victim's broken cell phone and a broken vase, all paint a portrait as to how the crime went down. According to the victim's family, he had no known enemies. A search warrant, along with analysis of the evidence and 3D crime scene scans; help to rule out a suspect. With no suspects or leads, Thompson turns to a recording of the victim's 911 call. In a surprising discovery, the victim named his killer during his last moments of life and the hunt is on.

Lead Homicide Detective Wally Everett and his partner Detective Mike Smith, are called out to a crime scene where a body lays hidden between some hedges and the porch of the victim's grandmother's house. The victim, a male, is face down. Strewn around the front lawn are seven bullet casings, evidence suggesting that the victim was shot multiple times. As detectives investigate the immediate area, they discover clues of the victim's alternate lifestyle - and they wonder if there may be a connection between that and his murder. Each piece of evidence takes them closer to their suspect and his motive.

Two men who live next to each other in a housing project get into a deadly argument. One is shot and killed. Detectives Crewell and Williams take the two men's girlfriends back to headquarters to find out what happened. One story tells of murder, the other self-defense. Detectives try to unravel the different accounts given by the girlfriends. The key may lie with a gun that was recovered from a trash can behind the house. A Federal lab tests a bullet found at the scene and the gun to determine if it is the murder weapon. Meanwhile, Crewell and Williams try to find holes in the girlfriend's stories. As the girlfriend's stories start to fall apart, the suspect on the run is feeling the heat.