When the parking garage where Monk's wife was killed is set for demolition, Monk intervenes -- but soon finds himself investigating the disappearance of a city official key to preserving the site. Tim Bagley and Jon Polito guest star.

Monk goes head-to-head with a magician he suspects of murder. Jarrad Paul and Steve Valentine guest star.

When a childhood bully who terrorized Monk hires the detective to trail his wife, whom he suspects of infidelity, Monk relishes the opportunity to prove him right -- and things get even sweeter when the bully is accused of murder. Julie Bowen and Noah Emmerich guest star.

Monk has scored tickets to the biggest football game of the year, but he and Captain Stottlemeyer can't go inside until they figure out who tried to blow up a fan in the parking lot. Bob Costas guest stars.

While investigating a murder at a museum of oddities, Monk befriends a warm older woman, but he has trouble believing the friendship comes without a catch. Gena Rowlands guest stars.

When Natalie unwittingly helps a thief steal the bicycle of a biotech CEO, she ropes Monk into solving a crime straight out of "Encyclopedia Brown" -- until Monk learns the hard way how dangerous this thief really is. Bradley Whitford guest stars.

When Monk's delinquent half-brother, Jack Jr., escapes from prison and breaks into Monk's apartment, he manipulates Monk into helping him find the person he claims framed him for murder. Steve Zahn guest stars as Jack Jr.

When three homeless men seek out Monk's services at the holidays, Natalie convinces him to investigate the death of their friend. Meanwhile, a skeptical Captain Stottlemeyer finds his faith re-awakened after a visit to a monastery fountain appears to rid him of crippling pain.

After Monk seeks a new form of therapy (hypnosis), he finds himself reverting to his 9-year old personality.

News magazine "In Focus" covers Monk's handling of a serial killer case (in which four people were killed) and the gang gathers for a viewing party to watch the piece. As Monk watches the interviews of his closest friends and adversaries, he realizes that something about the case leaves him unsettled. John Turturro, Eric McCormack, Sarah Silverman, Howie Mandel, Andy Richter, Brooke Adams and Angela Kinsey guest star in "Mr. Monk's 100th Case."